Organization: The Key to Reversing Cognitive Decline
TruNeura Founder interviewed on the MindHealth360 show
Today, a very special interview came out with Dr. Kristine Burke on the MindHealth360 show, whose host and founder is also the organizer of the Integrative Medicine for Mental Health (IMMH) Conference which is next week in San Diego.
What the conversation covers (and why it matters)
1) Brain health is systemic health
Dr. Burke connects memory, mood, and attention complaints to whole-body drivers - vascular/endothelial dysfunction, toxin and mold exposure, metabolic instability, hormone shifts (esp. in women), mitochondrial stress, sleep, and inflammation. This systems view is the through-line of MindHealth360’s integrative model and a hallmark of Burke’s practice.
2) The vascular lens most clinicians miss
Expect a deep dive into endothelial health and the glycocalyx as overlooked gatekeepers of brain perfusion and barrier integrity. Dr. Burke outlines practical testing (e.g., vascular inflammation markers, CIMT) and targeted nutrition/lifestyle strategies to restore the endothelium—an approach with direct implications for cognition.
3) Mold & mycotoxins: common, confusing, but treatable
Burke demystifies mold illness—when to suspect it, what to test (patient and home), and how to sequence care so the brain can actually recover once exposures are addressed. If you’re seeing “mysterious” fatigue, dysautonomia, MCAS-like reactivity, or cognitive slowing, this section alone is worth the listen.
4) Clinician workflow: from overwhelm to outcomes
The interview continually returns to process: clear intake frameworks, smart lab panels, staged interventions, and patient engagement loops. This is the difference between heroic, one-off care and a repeatable standard of care for cognitive decline.
8 Key Takeaways for Busy Clinicians
Think barriers: endothelial glycocalyx, blood-brain barrier, gut barrier—heal the gates, change the brain.
Screen vascular risk early in cognitive complaints; poor perfusion ≈ poor cognition.
Mold is a pattern, not a single lab. Correlate history, exposure, patient labs, and home testing.
Women’s brain health is different. Perimenopause requires a vascular-hormonal-metabolic lens.
Mitochondria matter. Light, movement, sleep, and metabolic flexibility are non-negotiables.
Sequence care: remove exposures, stabilize systems, then layer cognition-specific supports.
Measure what you modify: track vascular inflammation markers and clinical function over time.
Standardize your workflow so every new patient benefits from your best protocol, not your bandwidth.
Why TruNeura
TruNeura was designed for exactly this kind of care: root-cause, reproducible, data-driven brain health led by clinicians. Co-founded by Dr. Burke, TruNeura helps teams:
Structure intakes with a brain-health-first systems map
Streamline labs and automatically translate results into actionable care plans
Track progress (vascular, metabolic, cognitive; patient-reported + objective)
Scale your standard across providers and locations without losing nuance
If this episode had you nodding along, TruNeura is how you operationalize it on Monday.
Ready to see it in action?
Book a 25-minute TruNeura demo and we’ll show you how clinics like yours are delivering a higher standard of cognitive care with less prep time and clearer outcomes.
Triage smarter.
Personalize faster.
Track what matters.
Help more patients reverse course.
Request your demo now (pick a time that works for you).
About the guests
Dr. Kristine Burke, MD — Triple-boarded precision/functional medicine physician; founder & medical director at True Health Center for Precision Medicine (Northern California). Focus areas include cognitive decline, vascular/endothelial health, and mold-related illness.
Kirkland Newman — Founder/host of the MindHealth360 Show, a trusted platform for integrative, root-cause mental health education for patients and practitioners and organizer of IMMH Conference.